Valo Health's Posts (11)

Scientist I, Cell BiologistNew

About Us Valo Health is a technology company that is integrating human-centric data and AI-powered technology to accelerate the creation of life-changing drugs for more patients faster. Valo was created with the belief that the drug discovery and development process can and should be faster and less expensive, with a much higher probability of success. We are using models early to fail less often, executing clinical trials to add valuation to the company, and generating fit-for-purpose data to feed back into Valo’s Opal Computational Platform™ as we reinvent drug discovery and development from the ground up. Disease doesn’t wait, so neither can we. We are a multi-disciplinary team of experts in science, technology, and pharmaceuticals united in our mission to achieve better drugs for patients faster. Valo is committed to hiring diverse talent, prioritizing growth and development, fostering an inclusive environment, and creating opportunities to bring together a group of different experiences, backgrounds, and voices to work together. We achieve the widest-ranging impact when we leverage our broad backgrounds and perspectives to accelerate a new frontier in health. Valo seeks to become the catalyst for the pharmaceutical industry and drive the digital transformation of the industry. Are you ready to join us? What You’ll Do… Support drug discovery programs by developing disease-relevant cell culture models for use in downstream applications. The ideal candidate will bring their experience in cardiovascular, renal, and/or obesity biology to bear in support of various drug discovery programs. They will also exhibit a strong ability to work independently and within a matrixed team environment. All experiments will be documented in an electronic notebook, with data presented in routine informal or formal meetings. Essential Duties And Responsibilities What You Bring... - Develop disease-relevant cell culture models for use in downstream applications in collaboration with in vitro pharmacology colleagues - Conduct mechanism of action studies to elucidate target biology - Identify and characterize target engagement biomarkers - Leverage external service providers to supplement workstreams - BS (10+years experience), MS (6+ years experience), PhD degree (2 years experience) in cell biology, pharmacology, biotechnology or a related discipline - Experience with advanced biochemical, molecular, and cellular biology techniques such as CRISPR, iPSC, lentivirus, immunofluorescence, qRT-PCR, RNAi, western blot/protein analysis, ELISA, and cell viability/cytotoxicity assays. - Ability to work independently and as a cross-functional team-player i.e., able to achieve results as an individual and with/through colleagues. - Skilled at multi-tasking, prioritizing, and handling multiple projects at once. - Capable to adapt to dynamic working conditions. - Strong verbal and written communication skills. - Proficiency with Microsoft Office, Excel, PowerPoint, GraphPad Prism

Location: Lexington, Massachusetts, United States

Salary range: None - None

Associate Scientist, Cell Culture TechNew

About Us Valo Health is a technology company that is integrating human-centric data and AI-powered technology to accelerate the creation of life-changing drugs for more patients faster. Valo was created with the belief that the drug discovery and development process can and should be faster and less expensive, with a much higher probability of success. We are using models early to fail less often, executing clinical trials to add valuation to the company, and generating fit-for-purpose data to feed back into Valo’s Opal Computational Platform™ as we reinvent drug discovery and development from the ground up. Disease doesn’t wait, so neither can we. We are a multi-disciplinary team of experts in science, technology, and pharmaceuticals united in our mission to achieve better drugs for patients faster. Valo is committed to hiring diverse talent, prioritizing growth and development, fostering an inclusive environment, and creating opportunities to bring together a group of different experiences, backgrounds, and voices to work together. We achieve the widest-ranging impact when we leverage our broad backgrounds and perspectives to accelerate a new frontier in health. Valo seeks to become the catalyst for the pharmaceutical industry and drive the digital transformation of the industry. Are you ready to join us? What You’ll Do… What You Bring... More on Valo Valo Health, LLC (“Valo”) is a technology company built to transform the drug discovery and development process using human-centric data and artificial intelligence-driven computation. As a digitally native company, Valo aims to fully integrate human-centric data across the entire drug development life cycle into a single unified architecture, thereby accelerating the discovery and development of life-changing drugs while simultaneously reducing costs, time, and failure rates. The company’s Opal Computational Platform™ is an integrated set of capabilities designed to transform data into valuable insights that may accelerate discoveries and enable Valo to advance a robust pipeline of programs across cardiovascular metabolic renal, oncology, and neurodegenerative diseases. Founded by Flagship Pioneering and headquartered in Lexington, MA. Valo also has offices in New York, NY. To learn more, visit www.valohealth.com. - Work as part of a multifunctional team that include experts in biology, in vitro pharmacology, and ADME - Generate and maintain cell lines using aseptic techniques to support the cell biology and ADME efforts of our drug discovery programs. You will expand, maintain, and plate a diverse number of mammalian cell lines at any given time (including adherent/suspension immortalized cells, primary cells, stable cell lines, etc.). - Perform DNA/RNA transfections and viral transductions in a BSL-2 facility to establish in vitro cell models - Characterize the cell lines you generate, utilizing common techniques such as DNA/RNA isolation, PCR, qRT-PCR, siRNA knockdown, western blot/protein analysis, immunocytochemistry, ELISA, and cell viability/cytotoxicity assays - Optimize the maintenance conditions of a cell line (such as media selection, passages, freeze-thaws, gene knockdown efficiency, protein-of-interest expression levels, etc.) to enable the highest quality data of downstream applications - Keep detailed electronic records of both your work and the cellular stocks in liquid nitrogen - Adhere to safety regulations and good laboratory practices - At least a bachelor’s degree in a scientific discipline with 6+ years of relevant laboratory experience - Demonstrated experience in all steps of cell line generation, from initial genome modifications and clonal selections to cellular characterization and scale up - Proficiency using machines common in these workflows, such as a multidrop Combi, Apricot, Echo, thermocycler, cell counter, fluorescence microscope, and plate reader systems - Experience working with many types of mammalian cell lines (experience with iPSCs and iPSC differentiation is a plus) - Experience with CRISPR-Cas9 workflows, co-culture, organoids, or isolation of primary cells (including hepatocytes) is a plus - Strong written and oral communication skills and a demonstrated ability to convey information to program team members of varying backgrounds - Strong time management skills, with the ability to balance experiments for multiple programs and stakeholders - Ability to troubleshoot, think critically and independently, with excellent attention to detail

Location: Lexington, Massachusetts, United States

Salary range: None - None

Staff Machine Learning Data Scientist in Epidemiology and Patient Data Products

About Us Valo Health is a technology company that is integrating human-centric data and AI-powered technology to accelerate the creation of life-changing drugs for more patients faster. Valo was created with the belief that the drug discovery and development process can and should be faster and less expensive, with a much higher probability of success. We are using models early to fail less often, executing clinical trials to add valuation to the company, and generating fit-for-purpose data to feed back into Valo’s Opal Computational Platform™ as we reinvent drug discovery and development from the ground up. Disease doesn’t wait, so neither can we. We are a multi-disciplinary team of experts in science, technology, and pharmaceuticals united in our mission to achieve better drugs for patients faster. Valo is committed to hiring diverse talent, prioritizing growth and development, fostering an inclusive environment, and creating opportunities to bring together a group of different experiences, backgrounds, and voices to work together. We achieve the widest-ranging impact when we leverage our broad backgrounds and perspectives to accelerate a new frontier in health. Valo seeks to become the catalyst for the pharmaceutical industry and drive the digital transformation of the industry. Are you ready to join us? About the Role As aStaff Machine Learning Data Scientist in Epidemiology and Patient Data Products,you will be a core member on a team of data scientists building a powerful computational platform for advancing the discovery and development of new medicines. In this role, you will develop machine learning tools for patient data and expand their uptake across teams, under the guidance of epidemiology and biology program leads. Successful candidates will work with a diverse set of scientists and domain experts, in ways that cut across traditional industry boundaries in an innovative startup environment. What You'll Do... What You Bring... Nice to have... More on Valo Valo Health, Inc (“Valo”) is a technology company built to transform the drug discovery and development process using human-centric data and artificial intelligence-driven computation. As a digitally native company, Valo aims to fully integrate human-centric data across the entire drug development life cycle into a single unified architecture, thereby accelerating the discovery and development of life-changing drugs while simultaneously reducing costs, time, and failure rates. The company’s Opal Computational Platform™ is an integrated set of capabilities designed to transform data into valuable insights that may accelerate discoveries and enable Valo to advance a robust pipeline of programs across cardiovascular metabolic renal, oncology, and neurodegenerative disease. Founded by Flagship Pioneering and headquartered in Boston, MA, Valo also has offices in Lexington, MA, and New York. To learn more, visitwww.valohealth.com - As a senior member of our team, you will lead knowledge translation machine learning models and predictions of patient data with diverse stakeholders. For example, integrate clinical insights into unsupervised cluster results and generate patient profiles. - Perform hands-on analysis and modeling of highly dimensional longitudinal patient data, spanning electronic medical records, sequencing, and multi-omics, using R and Python in cloud environments. - Contribute to the design, implementation, and evaluation of innovative machine learning approaches of patient data to provide novel clinical insights. - Be comfortable with scientific uncertainty and embrace curiosity and creative solutions. Many of the challenges we’re trying to address don’t have known solutions or clear processes to arrive at answers. - Use your technical knowledge and intuition to articulate and break down large problems into solvable pieces. There are a lot of problems to solve; you’ll need to prioritize which of these are critical path today from those that can wait. - Be a dynamic and active team member, championing and adopting shared coding standards, participating in code review, and providing regular updates of your work and input into the work of your colleagues. - MPH, MS with 5+ years or PhD in health sciences, biostatistics, or a quantitative field with 3+ years of work-related experienceapplying epidemiological, statistical, and/or machine learning methods to real-world datasets. - Must have 3+ years of experiencedeveloping and implementing machine learning in health care databases including electronic health records, administrative claims databases, and/or patient registries. Familiarity with medical coding ontologies and data models in US and globally (ICD, ATC, LOINC, SNOMED, CPT, HCPCS, etc.). - Extensive experience developing and maintaining machine learning pipelines and translating machine learning output into meaningful insights for diverse audiences. - Confident in executing broad machine learning approaches, including random forest, logistic regression, dimensionality reduction, clustering, metrics, model selection, feature selection, and machine learning model explain ability. - Proficient in Python (3+ years required) and experience with machine learning, deep learning, and data science packages (e.g., scikit-learn, pytorch, statsmodels, scipy, MLlib). - Comfortable working in ambiguous problem spaces; experience working in a start-up or agile work environment as part of cross-functional project teams. - Ability to lead and facilitate meetings and work collaboratively on multi-disciplinary project teams. - Exceptional time management, ability to prioritize multiple tasks simultaneously, and deliver products on time every time. - Enthusiastic about documentation–ensuring that all analyses are clear and reproducible with thorough documentation of key assumptions and decision points. - Advanced knowledge of biostatistics approaches, including inferential and predictive modeling. Experience in causal approaches for observational studies, including propensity score methods, bias adjustment, and covariate selection and adjustment is a plus. - Familiarity with or exposure to traditional drug discovery and development processes and approaches is a plus. - Familiarity with integrated clinico–omics datasets (including sequencing, genomics, proteomics, etc.) is a plus.

Location: Remote

Salary range: None - None

Principal Scientist, ADME/PK

Valo Health is a technology company that is integrating human-centric data and AI-powered technology to accelerate the creation of life-changing drugs for more patients faster. Valo was created with the belief that the drug discovery and development process can and should be faster and less expensive, with a much higher probability of success. We are using models early to fail less often, executing clinical trials to add valuation to the company, and generating fit-for-purpose data to feed back into Valo’s Opal Computational Platform™ as we reinvent drug discovery and development from the ground up. Disease doesn’t wait, so neither can we. We are a multi-disciplinary team of experts in science, technology, and pharmaceuticals united in our mission to achieve better drugs for patients faster. Valo is committed to hiring diverse talent, prioritizing growth and development, fostering an inclusive environment, and creating opportunities to bring together a group of different experiences, backgrounds, and voices to work together. We achieve the widest-ranging impact when we leverage our broad backgrounds and perspectives to accelerate a new frontier in health. Valo seeks to become the catalyst for the pharmaceutical industry and drive the digital transformation of the industry. Are you ready to join us? Principal Scientist, ADME/PK will play a pivotal role in the Analytical Sciences group managing the day-to-day ADME lab operations and supporting Valo’s internal small molecule drug discovery programs focused on cardiovascular indications. Provide domain expertise representation to guide the multidisciplinary project teams and interpretation of ADME/PK results to propose/action next experimental steps. The position will require supervision of junior scientists’ work and a hands-on approach to managing assay schedules that provide the most pertinent ADME results in a cycle time that enables rapid evaluation of chemistry SAR. Oversee new technology initiatives and ADMET capabilities to support the needs of the growing portfolio and maintain high levels of data integrity. Valo Health, Inc (“Valo”) is a technology company built to transform the drug discovery and development process using human-centric data and artificial intelligence-driven computation. As a digitally native company, Valo aims to fully integrate human-centric data across the entire drug development life cycle into a single unified architecture, thereby accelerating the discovery and development of life-changing drugs while simultaneously reducing costs, time, and failure rates. The company’s Opal Computational Platform™ is an integrated set of capabilities designed to transform data into valuable insights that may accelerate discoveries and enable Valo to advance a robust pipeline of programs across cardiovascular metabolic renal, oncology, and neurodegenerative disease. Founded by Flagship Pioneering and headquartered in Lexington, MA, Valo also has an office in New York. To learn more, visitwww.valohealth.com. - Work closely with a team of experienced drug hunters to create novel, differentiated drug candidates, by providing strategic guidance and execution associated with in vitro and in vivo profiling. - Manage Valo’s internal high throughput & definitive ADME assay platform to support the small molecule preclinical pipeline (i.e., metabolic stability, drug permeability, drug-drug interaction, protein binding & solubility studies). - Identify, qualify, engage, and manage external providers of in vitro ADME and in vivo PK services; analyze and interpret resulting data. - Supervise and close mentorship/training of junior colleagues in the Analytical Sciences team. - Oversee day-to-day operation and maintenance of analytical technologies including tandem mass spec instrumentational and liquid handling automation. - Take the lead in establishing the best experimental ADME workflow practices to maintain a high level of data integrity and traceability.\ - Implementation of new emerging technologies/innovations/assays to advance discovery capabilities and operational efficiencies. - Partner closely with a team of AI/ML and data scientists to develop and implement a comprehensive and robust platform for in silico prediction of complex ADME/PK properties. - Recruit and train a versatile team to support growing portfolio needs. - Broad ADME experience and expertise spanning target assessment to later stage drug development, with an awareness of regulatory guidance and industry trends. - Well versed in the contemporary application of ADME assay automation, comprehensive workflow integration and data practices with LIMS/ELN software platforms. - Extensive hands-on experience in the design, qualification, and implementation of novel ADMET and physicochemical assays. - Leading-edge mindset in relation to current experimental and computational ADME/PK approaches and techniques.  Modeling and simulation expertise a plus (PBPK and QSP) - Ability to effectively communicate and influence in a dynamic and matrixed environment. - High-performing team mentality, able to lead, follow, and contribute based on the needs of the team and situation. - Success building and managing ADME-related specialties, with a continuous improvement mindset. Previous experience building and managing an ADME lab-based team a plus. - Ph.D. in a relevant scientific discipline and 8+ years of drug discovery experience or BS/MS and 15+ years

Location: Boston, Massachusetts, United States

Salary range: None - None

Director, Platform Engineering

Valo Health is a technology company that is integrating human-centric data and AI-powered technology to accelerate the creation of life-changing drugs for more patients faster. Valo was created with the belief that the drug discovery and development process can and should be faster and less expensive, with a much higher probability of success. We are using models early to fail less often, executing clinical trials to add valuation to the company, and generating fit-for-purpose data to feed back into Valo’s Opal Computational Platform™ as we reinvent drug discovery and development from the ground up. Disease doesn’t wait, so neither can we. We are a multi-disciplinary team of experts in science, technology, and pharmaceuticals united in our mission to achieve better drugs for patients faster. Valo is committed to hiring diverse talent, prioritizing growth and development, fostering an inclusive environment, and creating opportunities to bring together a group of different experiences, backgrounds, and voices to work together. We achieve the widest-ranging impact when we leverage our broad backgrounds and perspectives to accelerate a new frontier in health. Valo seeks to become the catalyst for the pharmaceutical industry and drive the digital transformation of the industry. Are you ready to join us? Valo is seeking an experiencedDirector of Engineeringto lead our efforts for our computational platform for drug discovery. You will manage a cross-functional team of data and software engineers, enhancing our state-of-the-art computational chemistry system. Your work will support both our external partnership and internal drug programs. In addition, you will be working closely with our Machine Learning, Data Science, and Medicinal Chemistry teams to accelerate the process of discovering new drug candidates. Valo Health, Inc (“Valo”) is a technology company built to transform the drug discovery and development process using human-centric data and artificial intelligence-driven computation. As a digitally native company, Valo aims to fully integrate human-centric data across the entire drug development life cycle into a single unified architecture, thereby accelerating the discovery and development of life-changing drugs while simultaneously reducing costs, time, and failure rates. The company’s Opal Computational Platform™ is an integrated set of capabilities designed to transform data into valuable insights that may accelerate discoveries and enable Valo to advance a robust pipeline of programs across cardiovascular metabolic renal, oncology, and neurodegenerative disease. Founded by Flagship Pioneering and headquartered in Lexington, MA, Valo also has an office in New York. To learn more, visitwww.valohealth.com. - Manage, mentor, and grow an engineering team of 4-6 between our San Francisco and Boston offices. - Lead the evolution of Valo’s data science platform, ensuring it is robust, scalable and meets the high-performance demands of our data scientists, all while upholding data governance standards. - Drive cross-functional collaboration across our data science, machine learning, lab informatics, and medicinal chemistry teams to advance our computational infrastructure for our drug discovery and development mission. - Foster processes and technology to boost operational scalability, enabling our teams to rapidly expand capacity without expanding headcount. - 10+ years of experience in software engineering and leadership - 4+ years of management experience managing cross-functional teams. - Experience in creating an effective and inclusive team culture. - Experience building data science platforms: data and feature engineering pipelines, model life-cycle support, data governance. - Demonstrated ability to effectively communicate with and influence business and technical teams - A strong understanding of AWS technologies for Cloud native applications and services - B.S. or M.S. in Computer Science or a similar technical field, or equivalent experience - A background in drug development or another healthcare or biotechnology field - Experience with data science and workflow orchestration platforms such as Domino, Kubeflow, Prefect, Ray, Spark - Experience with AWS infrastructure and MLOps services such as EKS and SageMaker

Location: Boston, Massachusetts, United States

Salary range: None - None

1 2 3